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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-NYX-2925
NYX-2925

Chemical Structure : NYX-2925

CAS No.: 2012536-16-0

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NYX-2925 (NYX2925)

货号: PC-20695Not For Human Use, Lab Use Only.

NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively.
    NYX-2925 does not exhibit any significant affinity for a large panel of neuroactive receptors, including hERG receptors.
    NYX-2925 increased MK-801 binding to human N-methyl-D-aspartate receptor NR2A-D subtypes expressed in HEK cells and enhanced N-methyl-D-aspartate receptor current and long-term potentiation (LTP) in rat hippocampal slices (100–500 nM).
    NYX-2925 showed increased metaplasticity in a hippocampal LTP paradigm and structural plasticity 24 hours after administration (1 mg/kg p.o.).
    NYX-2925, like rapastinel, activates an NMDA receptor-mediated synaptic plasticity process and may have therapeutic potential for a variety of NMDA receptor-mediated central nervous system disorders.

    物理化学性质&存储条件

    分子量 297.36
    分子式 C14H23N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S,3R)-3-hydroxy-2-((S)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide

    参考文献

    1. Ghoreishi-Haack N, et al. J Pharmacol Exp Ther. 2018 Sep;366(3):485-497.

    2. Khan MA, et al. Int J Neuropsychopharmacol. 2018 Mar 1;21(3):242-254.

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