NYX-1492 | PCSK9 inhibitor | Probechem Biochemicals

Chemical Structure : NYX-1492

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NYX-1492 (PCSK-287, NYX1492)

货号: PC-21266Not For Human Use, Lab Use Only.

NYX-1492 is a small molecule PCSK9 inhibitor, blocks PCSK9 binding with the LDLR, attenuates inflammation in vascular cells and tissue-engineered blood vessels (TEBVs).

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生物&药学活性

NYX-1492 is a small molecule PCSK9 inhibitor, blocks PCSK9 binding with the LDLR, attenuates inflammation in vascular cells and tissue-engineered blood vessels (TEBVs).
NYX-1492 reduces monocyte adhesion in P+ TEBVs with evidence of lowering secretion of VCAM-1 and TNF-α.

物理化学性质&存储条件

分子量	581.59
分子式	C31H28F5N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-((3-amino-4,4-difluoropiperidin-1-yl)methyl)-5-(6-(trifluoromethyl)pyridin-3-yl)phenyl)-5-methyl-4-phenylpicolinamide

参考文献

1. Jounghyun H Lee, et al. APL Bioeng. 2023 Oct 16;7(4):046103.

NYX-1492 (PCSK-287, NYX1492)

生物&药学活性

物理化学性质&存储条件

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询单

NYX-1492 (PCSK-287, NYX1492)

生物&药学活性

物理化学性质&存储条件

参考文献

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