NY0116 | NMUR2 agonist | Probechem Biochemicals

Chemical Structure : NY0116

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NY0116 (NY 0116, NY-0116)

货号: PC-35773Not For Human Use, Lab Use Only.

NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.

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生物&药学活性

NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.
NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
NY0116 significantly decreased high-fat diet consumption in vivo after acute administration, decreased body weight and more specifically, decreased the percentage of visceral adipose tissue (VAT) in obese mice after repeated administration.

物理化学性质&存储条件

分子量	345.446
分子式	C22H23N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(trityloxy)ethyl)guanidine

参考文献

1. Sampson CM, et al. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425.

NY0116 (NY 0116, NY-0116)

生物&药学活性

物理化学性质&存储条件

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NY0116 (NY 0116, NY-0116)

生物&药学活性

物理化学性质&存储条件

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