NXT629 | PPARα antagonist | Probechem Biochemicals

Chemical Structure : NXT629

CAS No.: 1454925-59-7

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NXT629 (NXT-629)

货号: PC-72656Not For Human Use, Lab Use Only.

NXT629 (NXT-629) is a potent, selective PPARα antagonist with IC50 of 78 nM, no effect against PPARδ and PPARγ (IC50>30 uM).

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5 mg	￥4580	In stock
10 mg	￥7280	In stock
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生物&药学活性

NXT629 (NXT-629) is a potent, selective PPARα antagonist with IC50 of 77 nM (human PPARα), no effect against PPARδ and PPARγ (IC50>30 uM).
NXT629 inhibited agonist-induced transcription of PPARα-regulated genes, demonstrating target engagement in chronic lymphocytic leukemia (CLL) cells.
NXT629 induced apoptosis of CLL cells even in the presence of a protective microenvironment.
NXT629 reduces the number of chronic leukemia cells undergoing cell division with IC50 of 9.6 uM.
NXT629 reduces CLL tumor burden delays disease progression of CLL in CLL mouse model.

物理化学性质&存储条件

分子量	609.789
分子式	C35H39N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (60.9 mg/mL)
Chemical Name/SMILES	N-(6-(4-(3-(1-(4-(tert-Butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenyl)pyridin-3-yl)benzenesulfonamide

参考文献

1. Messmer D, et al. Mol Med. 2015 Jun 9;21(1):410-9.

2. Stebbins KJ, et al. Eur J Pharmacol. 2017 Aug 15;809:130-140.

NXT629 (NXT-629)

生物&药学活性

物理化学性质&存储条件

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NXT629 (NXT-629)

生物&药学活性

物理化学性质&存储条件

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