NX-13 (Amelenodor)

Chemical Structure : NX-13

CAS No.: 2389235-01-0

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货号: PC-49115Not For Human Use, Lab Use Only.

NX-13 (Amelenodor) is an orally active, gut-restricted NLRX1 agonist, has in situ binding effects on the stability of NLRX1 with EC50 of 58 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NX-13 (Amelenodor) is an orally active, gut-restricted NLRX1 agonist, has in situ binding effects on the stability of NLRX1 with EC50 of 58 nM.
NX-13 modulates CD4+ T cell differentiation and metabolism, NX-13 significantly decreased the differentiation of Th1 and Th17 at 0.05 μM with a dose response and suppressive effect down to 0.005 μM.
NX-13 (10 mg/kg, oral) reduces inflammation in a model of DSS colitis.
NX-13 reduces inflammation and alters NLRX1 signaling in PBMCs from ulcerative colitis (UC) patients, decreases NF-κB activity, TNFα+ and IFNγ+ CD4+ T cells and overall production of IL-6, MCP1 and IL-8.
NX-13 is a promising immunometabolic oral, gut-restricted therapeutic for CD and UC that is effective at reducing inflammation in DSS, adoptive transfer and Mdr1a−/− mouse models of IBD plus in in vitro studies using primary murine and human cells.
NLRX1 (Nucleotide-binding oligomerization domain, leucine rich repeat containing X1) is a mitochondria-associated receptor involved in down-regulating inflammation during bacterial and viral exposure, acute non-infectious colitis, colorectal cancer and chronic pulmonary disease.

物理化学性质&存储条件

分子量	399.450
分子式	C24H21N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3,5-tris (6-methylpyridin-2-yloxy) benzene

参考文献

1. Leber A, et al. J Immunol. 2019 Dec 15;203(12):3407-3415.

NX-13 (Amelenodor)

生物&药学活性

物理化学性质&存储条件

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NX-13 (Amelenodor)

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