NVS-MELK8a hydrochloride | MELK inhibitor | Probechem Biochemicals

Chemical Structure : NVS-MELK8a hydrochloride

CAS No.: 2096992-20-8

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NVS-MELK8a hydrochloride (MELK8a hydrochloride)

货号: PC-42114Not For Human Use, Lab Use Only.

NVS-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

NVS-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.
NVS-MELK8a exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM).
NVS-MELK8a exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.

物理化学性质&存储条件

分子量	469.02212
分子式	C25H33ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 8.6 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-,hydrochloride

参考文献

1. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23.

2. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.

NVS-MELK8a hydrochloride (MELK8a hydrochloride)

生物&药学活性

物理化学性质&存储条件

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NVS-MELK8a hydrochloride (MELK8a hydrochloride)

生物&药学活性

物理化学性质&存储条件

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