NVP-TAE226 | FAK/Pyk2 inhibitor | Probechem Biochemicals

Chemical Structure : NVP-TAE226

CAS No.: 761437-28-9

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NVP-TAE226 (TAE-226;TAE226)

货号: PC-43388Not For Human Use, Lab Use Only.

NVP-TAE226 (TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM, also potently inhibits Pyk2 (IC50=5 nM), 10- to 100-fold less potent against IR, IGF-IR, ALK, and c-Met kinases.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

NVP-TAE226 (TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM, also potently inhibits Pyk2 (IC50=5 nM), 10- to 100-fold less potent against IR, IGF-IR, ALK, and c-Met kinases.
TAE226 suppresses the growth and invasion of glioma cells, inhibits extracellular matrix-induced autophosphorylation of FAK Tyr397.
TAE226 also inhibits IGF-I-induced phosphorylation of IGF-IR and activity of its downstream target genes such as MAPK and Akt.
TAE226 significantly increases the survival rate of animals in glioma xenograft model.

物理化学性质&存储条件

分子量	468.936
分子式	C23H25ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-

参考文献

1. Halder J, et al. Cancer Res. 2007 Nov 15;67(22):10976-83.

2. Liu TJ, et al. Mol Cancer Ther. 2007 Apr;6(4):1357-67.

3. Watanabe N, et al. Clin Cancer Res. 2008 Jul 15;14(14):4631-9.

4. Sakurama K, et al. Mol Cancer Ther. 2009 Jan;8(1):127-34.

NVP-TAE226 (TAE-226;TAE226)

生物&药学活性

物理化学性质&存储条件

参考文献

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NVP-TAE226 (TAE-226;TAE226)

生物&药学活性

物理化学性质&存储条件

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