NVP-SAA164

Chemical Structure : NVP-SAA164

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货号: PC-26636Not For Human Use, Lab Use Only.

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生物&药学活性

NVP-SAA164 is a potent, selective orally active nonpeptide bradykinin B1 receptor (B1R) antagonist with Ki of 8 nM, inhibits increases in intracellular calcium induced by desArg10kallidin (desArg10KD) with IC50 of 33 nM.
NVP-SAA164 shows high affinity in monkey fibroblasts with Ki of 7.7 nM, shows no affinity for the rat B1 receptor expressed in Cos-7 cells.
NVP-SAA164 exhibits marked selectivity for the human receptor, with no affinity for the rat B1 receptor.
Oral administration of NVP-SAA164 produced a dose-related reversal of FCA-induced mechanical hyperalgesia and desArg10KD-induced hyperalgesia in hB1-KI mice.

物理化学性质&存储条件

分子量	659.85
分子式	C36H45N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [2-[(2,2-diphenylethyl)amino]-5-[[4-[(4-methyl-1-piperazinyl)carbonyl]-1-piperidinyl]sulfonyl]phenyl]-4-morpholinyl-

参考文献

1. Alyson Fox, et al. Br J Pharmacol. 2005 Apr;144(7):889-99.

NVP-SAA164

生物&药学活性

物理化学性质&存储条件

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NVP-SAA164

生物&药学活性

物理化学性质&存储条件

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