NVP-QAV680 | CRTH2 inhibitor | Probechem Biochemicals

Chemical Structure : NVP-QAV680

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NVP-QAV680 (QAV-680)

货号: PC-20091Not For Human Use, Lab Use Only.

NVP-QAV680 (QAV680) is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM and IC50 of 147 nM in 3H-PGD2 filtration binding assays and cAMP whole cell assays, respectively.

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生物&药学活性

NVP-QAV680 (QAV680) is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM and IC50 of 147 nM in 3H-PGD2 filtration binding assays and cAMP whole cell assays, respectively.
NVP-QAV680 displays no significant activities against a panel of prostanoid receptors and related eicosanoid targets at 10 uM.
NVP-QAV680 inhibits DK-PGD2 induced IL-5 and IL-13 from primary cultured human CD4+ Th2 lymphocytes with IC50 of 52 and 25 nM, respectively.
NVP-QAV680 (10 mg/kg, p.o.) inhibits DK-PGD2-induced pulmonary eosinophilia in Sprague-Dawley rats.

物理化学性质&存储条件

分子量	358.41
分子式	C18H18N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-methyl-1-(4-(methylsulfonyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid

参考文献

1. Sandham DA, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91.

NVP-QAV680 (QAV-680)

生物&药学活性

物理化学性质&存储条件

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NVP-QAV680 (QAV-680)

生物&药学活性

物理化学性质&存储条件

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