NVP-BSK805 dihydrochloride |CAS: Probechem Biochemicals

Chemical Structure : NVP-BSK805 dihydrochloride

CAS No.: 1942919-79-0

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NVP-BSK805 dihydrochloride (BSK805 dihydrochloride;NVP-BSK 805 dihydrochloride)

货号: PC-44040Not For Human Use, Lab Use Only.

NVP-BSK805 dihydrochloride is a potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NVP-BSK805 dihydrochloride is a potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM).
NVP-BSK805 displays >20-fold selectivity towards JAK1, JAK3, TYK2 and excellent selectivity in broader kinase profiling.
NVP-BSK805 blunts constitutive STAT5 phosphorylation in JAK2(V617F)-bearing cells.
NVP-BSK805 exhibits good oral bioavailability and a long half-life.

物理化学性质&存储条件

分子量	563.4695
分子式	C27H30Cl2F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine dihydrochloride

参考文献

1. Baffert F, et al. Mol Cancer Ther. 2010 Jul;9(7):1945-55.

2. Pissot-Soldermann C, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2609-13.

NVP-BSK805 dihydrochloride (BSK805 dihydrochloride;NVP-BSK 805 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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NVP-BSK805 dihydrochloride (BSK805 dihydrochloride;NVP-BSK 805 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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