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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Ephrin Receptor-NVP-BHG712
NVP-BHG712

Chemical Structure : NVP-BHG712

CAS No.: 940310-85-0

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NVP-BHG712 (NVP-BHG 712;NVP BHG 712)

货号: PC-43438Not For Human Use, Lab Use Only.

NVP-BHG712 is a potent, specific inhibitor of EphB4 kinase that inhibits EphB4 autophosphorylation with IC50 of 25 nM in cell-bases assays, displays little to no activity against VEGFR2, IGF1R and InsR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NVP-BHG712 is a potent, specific inhibitor of EphB4 kinase that inhibits EphB4 autophosphorylation with IC50 of 25 nM in cell-bases assays, displays little to no activity against VEGFR2, IGF1R and InsR.
NVP-BHG712 dose dependently inhibits autophosphorylation of the EphRs, showing some preference for EphB4 followed by inhibition of EphB2, EphA2, EphB3 and EphA3.
NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration, inhibits VEGF driven tissue growth and angiogenesis in vivo.

物理化学性质&存储条件

分子量 503.48
分子式 C26H20F3N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-

参考文献

1. Martiny-Baron G, et al. Angiogenesis. 2010 Sep;13(3):259-67.

2. Kathawala RJ, et al. Oncotarget. 2015 Jan 1;6(1):510-21.

3. Wnuk M, et al. Kidney Int. 2012 Jun;81(12):1212-25.

4. Becerikli M, et al. Int J Cancer. 2015 Apr 15;136(8):1781-91.

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