Infigratinib phosphate (NVP-BGJ398) | FGFR inhibitor | Probechem Biochemicals

Chemical Structure : NVP-BGJ398 phosphate

CAS No.: 1310746-10-1

加入收藏

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ-398 phosphate)

货号: PC-43485Not For Human Use, Lab Use Only.

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.

规格	价格	库存
10 mg	￥580	In stock
50 mg	￥1180	In stock
100 mg	￥1880	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.
Infigratinib phosphate (NVP-BGJ398) inhibits the proliferation of the FGFR1-, FGFR2-, and FGFR3-dependent BaF3 cells with IC50 of low nanomolar range.
Infigratinib phosphate (NVP-BGJ398) shows significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3, significantly inhibits the growth of FGFR2-mutated endometrial cancer xenograft models, also ameliorates FGF23-mediated hypophosphatemic rickets in mouse models.

物理化学性质&存储条件

分子量	658.47
分子式	C26H34Cl2N7O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, phosphate (1:1)

参考文献

1. Guagnano V, et al. J Med Chem. 2011 Oct 27;54(20):7066-83.

2. Guagnano V, et al. Cancer Discov. 2012 Dec;2(12):1118-33.

3. Konecny GE, et al. Mol Cancer Ther. 2013 May;12(5):632-42.

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ-398 phosphate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ-398 phosphate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.