NVP-AEW541 | IGF-1R inhibitor | Probechem Biochemicals

Chemical Structure : NVP-AEW541

CAS No.: 475489-16-8

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NVP-AEW541 (AEW-541;AEW541;AEW 541;NVP AEW541)

货号: PC-45879Not For Human Use, Lab Use Only.

NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
NVP-AEW541 shows weak activity for closely related InsR (IC50=2.3 uM).
NVP-AEW541 inhibits IGF-IR autophosphorylation and abrogates IGF-I-mediated survival and colony formation in soft agar.
NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas in vivo; orally bioavailable.

物理化学性质&存储条件

分子量	439.5521
分子式	C27H29N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-

参考文献

1. García-Echeverría C, et al. Cancer Cell. 2004 Mar;5(3):231-9.

2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.

3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.

NVP-AEW541 (AEW-541;AEW541;AEW 541;NVP AEW541)

生物&药学活性

物理化学性质&存储条件

参考文献

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NVP-AEW541 (AEW-541;AEW541;AEW 541;NVP AEW541)

生物&药学活性

物理化学性质&存储条件

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