NVP-AEE788 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : NVP-AEE788

CAS No.: 497839-62-0

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NVP-AEE788 (AEE788, AEE-788)

货号: PC-42158Not For Human Use, Lab Use Only.

NVP-AEE788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
100 mg	￥3680	In stock
250 mg		Get quote

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生物&药学活性

NVP-AEE788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
NVP-AEE788 (AEE788) inhibits growth factor-induced EGFR and ErbB2 phosphorylation in cells with IC50 of 11 and 220 nM, respectively.
NVP-AEE788 (AEE788) demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines.
NVP-AEE788 (AEE788) shows antitumor and antiangiogenic activity in vivo.

物理化学性质&存储条件

分子量	440.5832
分子式	C27H32N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10 mM
Chemical Name/SMILES	7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-

参考文献

1. Traxler P, et al. Cancer Res. 2004 Jul 15;64(14):4931-41.

2. Goudar RK, et al. Mol Cancer Ther. 2005 Jan;4(1):101-12.

3. Park YW, et al. Clin Cancer Res. 2005 Mar 1;11(5):1963-73.

NVP-AEE788 (AEE788, AEE-788)

生物&药学活性

物理化学性质&存储条件

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NVP-AEE788 (AEE788, AEE-788)

生物&药学活性

物理化学性质&存储条件

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