NV-6297 | GLUT-1 inhibitor | Probechem Biochemicals

Chemical Structure : NV-6297

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NV-6297 (NV6297)

货号: PC-20248Not For Human Use, Lab Use Only.

NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.

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生物&药学活性

NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
NV-6297 shows improved pharmacokinetics and oral bioavailability compared with NV-5440.
NV-6297 potently inhibits glucose uptake in MCF7 cells with IC50 of 0.06 uM.

物理化学性质&存储条件

分子量	587.74
分子式	C31H37N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(3-((1-(2-cyanophenyl)piperidin-4-yl)amino)-2,4,6-trimethylbenzoyl)piperazin-1-yl)pyridine-3-sulfonamide

参考文献

1. Kang SA, et al. Cell Chem Biol. 2019 Sep 19;26(9):1203-1213.e13.

NV-6297 (NV6297)

生物&药学活性

物理化学性质&存储条件

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NV-6297 (NV6297)

生物&药学活性

物理化学性质&存储条件

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