NUCC-555 | Activin inhibitor | Probechem Biochemicals

Chemical Structure : NUCC-555

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NUCC-555 (NUCC555)

货号: PC-21392Not For Human Use, Lab Use Only.

NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.

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生物&药学活性

NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.
NUCC-555 binds to the activin A:ActRII that disrupts the activin A:ActRII complex's binding with ALK4-ECD-Fc in a dose-dependent manner.
NUCC-555 also specifically binds to activin A compared with other TGFβ superfamily member myostatin (GDF8).
NUCC-555 completely blocks activin A/ActRIIA complex binding with ALK4 at 25 uM, shows no blocking activity to the myostatin/ActRIIA complex binding with ALK4.
NUCC-555 not only strongly antagonizes function against activin A but also has selectivity for binding to activin A over other TGFβ superfamily members, such as myostatin.
NUCC-555 (30 or 60 mg/kg) treatment induces a dose-dependent decrease in FSH levels in ovariectomized mice.

物理化学性质&存储条件

分子量	443.51
分子式	C25H25N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-benzyl-1-ethyl-5-(2-methoxyacetamido)-2-(pyridin-3-yl)-1H-benzo[d]imidazole-7-carboxamide

参考文献

1. Jie Zhu, et al. J Med Chem. 2015 Jul 23;58(14):5637-48.

NUCC-555 (NUCC555)

生物&药学活性

物理化学性质&存储条件

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NUCC-555 (NUCC555)

生物&药学活性

物理化学性质&存储条件

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