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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MNK-NUCC-0200808
NUCC-0200808

Chemical Structure : NUCC-0200808

CAS No.:

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NUCC-0200808 (NUCC0200808)

货号: PC-24272Not For Human Use, Lab Use Only.

NUCC-0200808 is a potent selective, orally bioavailable inhibitor of mitogen-activated protein kinase (MAPK) interacting kinase MNK1 and MNK2 with IC50 of 42 nM and 29 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NUCC-0200808 is a potent selective, orally bioavailable inhibitor of mitogen-activated protein kinase (MAPK) interacting kinase MNK1 and MNK2 with IC50 of 42 nM and 29 nM, respectively.
NUCC-0200808 inhibit phosphorylation of Ser209 on eIF4E with IC50 < 100 nM in MV4-11 and U937 cells.
NUCC-0200808 decreases the viability of U937 and MV4-11 cells with 4.7 and 0.27 μM, respectively, induces apoptosis.

物理化学性质&存储条件

分子量 315.76
分子式 C15H14ClN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(5-chloro-4-(pyrrolidin-3-yloxy)pyrimidin-2-yl)-1H-benzo[d]imidazole

参考文献

1. Vagadia PP, et al. J Med Chem. 2025 Mar 3. doi: 10.1021/acs.jmedchem.4c03158.

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