NUCC-0200590 | TRIP8b-HCN inhibitor | Probechem Biochemicals

Chemical Structure : NUCC-0200590

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NUCC-0200590 (NUCC0200590)

货号: PC-38762Not For Human Use, Lab Use Only.

NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.

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生物&药学活性

NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
NUCC-0200590 (5 uM) disrupts TRIP8b mediated HCN channel regulation in HEK cells.
NUCC-0200590 (15 uM) reduces sag ratio in CA1 pyramidal neurons of mouse brain slices.
NUCC-0200590 limits dendritic expression of HCN channels in CA1 region of the hippocampus.

物理化学性质&存储条件

分子量	482.00
分子式	C27H29ClFN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorobenzyl)-2-((4'-fluoro-3-((4-methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)oxy)acetamide

参考文献

1. Ye Han, et al. J Biol Chem Available online 24 May 2022, 102069

NUCC-0200590 (NUCC0200590)

生物&药学活性

物理化学性质&存储条件

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NUCC-0200590 (NUCC0200590)

生物&药学活性

物理化学性质&存储条件

参考文献

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