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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA-PK-NU-7163
NU-7163

Chemical Structure : NU-7163

CAS No.: 503468-03-9

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NU-7163 (NU7163;NU 7163)

货号: PC-70103Not For Human Use, Lab Use Only.

NU-7163 is a poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NU-7163 is a poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM.
    NU-7163 exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α。
    NU-7163 sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro.

    物理化学性质&存储条件

    分子量 295.338
    分子式 C18H17NO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-methylmorpholino)-4H-benzo[h]chromen-4-one

    参考文献

    1. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85.

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