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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-NU-6300
NU-6300

Chemical Structure : NU-6300

CAS No.: 2070015-09-5

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NU-6300 (NU 6300;NU6300)

货号: PC-45559Not For Human Use, Lab Use Only.

NU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.
NU-6300 shows modest effect (GI50=8 uM) against human MCF-7 breast carcinoma cells.
NU-6300 inhibits Rb phosphorylation in Rb-positive SKUT-1B cells.

物理化学性质&存储条件

分子量 413.4933
分子式 C20H23N5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine

参考文献

1. Anscombe E, et al. Chem Biol. 2015 Sep 17;22(9):1159-64.

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