NTRC 0066-0 |CAS:1817791-73-3 Probechem Biochemicals

Chemical Structure : NTRC 0066-0

CAS No.: 1817791-73-3

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NTRC 0066-0 (NTRC0066-0)

货号: PC-61464Not For Human Use, Lab Use Only.

NTRC 0066-0 is a highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

NTRC 0066-0 is a highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM.
NTRC 0066-0 displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4.
NTRC 0066-0 shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM).
NTRC 0066-0 increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel.

物理化学性质&存储条件

分子量	565.722
分子式	C33H39N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-4,5-dihydro-7,9,9b-triaza-cyclopenta[a]naphthalene-3-carboxylic acid (2,6-diethyl-phenyl)-amide

参考文献

1. Maia AR, et al. Ann Oncol. 2015 Oct;26(10):2180-92.

2. Libouban MAA, et al. Oncotarget. 2017 Jun 13;8(24):38309-38325.

3. Zaman GJR, et al. Mol Cancer Ther. 2017 Jul 27. pii: molcanther.0342.2017.

NTRC 0066-0 (NTRC0066-0)

生物&药学活性

物理化学性质&存储条件

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NTRC 0066-0 (NTRC0066-0)

生物&药学活性

物理化学性质&存储条件

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