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首页-小分子抑制剂&激动剂-Others-Other Targets-NTE-122
NTE-122

Chemical Structure : NTE-122

CAS No.: 166967-84-6

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NTE-122 (NTE122)

货号: PC-49561Not For Human Use, Lab Use Only.

NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM.
    NTE-122 displays no effect on other lipid metabolizing enzymes, such as 3-hydroxy-3-methylglutaryl-CoA reductase, acyl-CoA synthetase, cholesterol esterase, lecithin:cholesterol acyltransferase, acyl-CoA:sn-glycerol-3-phosphate acyltransferase and cholesterol 7alpha-hydroxylase up to 10 uM.
    NTE-122 markedly reduced serum and liver cholesterol levels in the cholesterol diet-fed rats, with ED50 of 0.12 and 0.44 mg/kg/day, respectively.
    NTE-122 significantly lowered plasma and liver cholesterol levels at more than 2 mg/kg/day in the cholesterol diet-fed rabbits.

    物理化学性质&存储条件

    分子量 703.83
    分子式 C38H60Cl2N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Urea, N,N′′-[1,4-cyclohexanediylbis(methylene)]bis[N-cyclohexyl-N′-[4-(dimethylamino)phenyl]-, dihydrochloride, trans-

    参考文献

    1. Azuma Y, et al. Jpn J Pharmacol. 1998 Nov;78(3):355-64.

    2. Azuma Y, et al. Jpn J Pharmacol. 1999 Feb;79(2):159-67.

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