NTCP binder peptide WL4

Chemical Structure : NTCP binder peptide WL4

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货号: PC-35637Not For Human Use, Lab Use Only.

NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM.
WL4 also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains).
WL4 exhibits no inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.

物理化学性质&存储条件

分子量	1944.245
分子式	C99H122N20O20S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclo-S-Ac-Tyr-Phe-Ile-Ile-ValMe-Gly-Thr-Trp-Thr-Trp-Thr-Trp-Ser-Cys-Thr-NH2

参考文献

1. Passioura T, et al. Cell Chem Biol. 2018 Jul 19;25(7):906-915.e5.