NT376 | class IIa HDAC inhibitor | Probechem Biochemicals

Chemical Structure : NT376

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NT376 (NT-376)

货号: PC-22549Not For Human Use, Lab Use Only.

NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes.

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生物&药学活性

NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes.
NT376 shows binding potency with cellular IC50 of 46 nM.
NT376 shows high potency against class-IIa HDAC4 and 5 isoforms and low potency to isoforms from other HDAC classes (HDAC1, class-I; HDAC6, class-IIb; and HDAC11, class-IV).

物理化学性质&存储条件

分子量	436.41
分子式	C21H20F4N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-(benzyl(methyl)amino)propan-2-yl)-2-fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

参考文献

1. Xu S, et al. Sci Rep. 2024 Jul 2;14(1):15100.

NT376 (NT-376)

生物&药学活性

物理化学性质&存储条件

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NT376 (NT-376)

生物&药学活性

物理化学性质&存储条件

参考文献

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