NSD1 inhibitor BT5 | NSD1 inhibitor | Probechem Biochemicals

Chemical Structure : NSD1 inhibitor BT5

CAS No.: 2351225-46-0

加入收藏

NSD1 inhibitor BT5 (BT5)

货号: PC-72299Not For Human Use, Lab Use Only.

NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2.
BT5 displays liitle to no affinity against selected epigenetic enzymes, including 10 HDACs, 4 sirtuins and 6 HATs revealed no significant activity of BT5 at 50 uM.
BT5 demonstrates on-target activity in cells and blocks proliferation of NUP98-NSD1 cells with GI50 of 0.8-1.3 uM, human leukemia cell lines (K562, MOLM13 and SET2) with GI 50 of 6 uM.
BT5 inhibits NSD1 SET domain and impairs the activity of NUP98-NSD1 in leukemia cells, reduces the H3K36me2 level but not H3K36me3.
BT5 impairs colony formation in NUP98-NSD1 patient sample MLL-ENL translocation, reduces HOXA9 and MEIS1 expression, without cytotoxicity on normal CD34+ bone marrow progenitor cells.

物理化学性质&存储条件

分子量	221.278
分子式	C10H11N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-6-(2-methylaziridin-1-yl)-1,3-benzothiazol-4-ol

参考文献

1. Huang H, et al. Nat Chem Biol. 2020 Dec;16(12):1403-1410.

NSD1 inhibitor BT5 (BT5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NSD1 inhibitor BT5 (BT5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.