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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-NSC95682
NSC95682

Chemical Structure : NSC95682

CAS No.: 20035-41-0

NSC95682 (3-Methoxy-6-bromosalicylaldehyde)

货号: PC-70078Not For Human Use, Lab Use Only.

NSC95682 is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC95682 is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM.
NSC95682 binds to IRE1 in a specific, reversible and dose-dependent manner and inhibits XBP-1 splicing induced pharmacologically in human cells.
NSC95682 inhibits XBP-1 splicing in vivo model of acute ER stress.

物理化学性质&存储条件

分子量 231.045
分子式 C8H7BrO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Methoxy-6-bromosalicylaldehyde

参考文献

1. Volkmann K, et al. J Biol Chem. 2011 Apr 8;286(14):12743-55.

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