NSC 87877 |CAS:56990-57-9 Probechem Biochemicals

Chemical Structure : NSC 87877

CAS No.: 56990-57-9

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NSC 87877 (NSC87877;NSC-87877)

货号: PC-61176Not For Human Use, Lab Use Only.

NSC 87877 is potent, selective protein tyrosine phosphatase SHP1 and SHP2 with IC50 of 318 and 355 nM, respectively, also inhibits dual-specificity phosphatase 26 (DUSP26).

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

NSC 87877 is potent, selective protein tyrosine phosphatase SHP1 and SHP2 with IC50 of 318 and 355 nM, respectively, also inhibits dual-specificity phosphatase 26 (DUSP26).
NSC 87877 displays 5-fold selectivity over PTP1B, 20-fold over HePTP and no activity against DEP1, CD45 and LAR.
NSC 87877 also effectively inhibits DUSP26-mediated dephosphorylation of p38.
NSC 87877 inhibits EGF-induced activation of Shp2 PTP, Ras, and Erk1/2 in cell cultures, inhibits EGFRvIII oncogenic transformation in human glioblastoma cells.

物理化学性质&存储条件

分子量	459.45
分子式	C19H13N3O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid

参考文献

1. Chen L, et al. Mol Pharmacol. 2006 Aug;70(2):562-70.

2. Langdon YG, et al. Development. 2007 Nov;134(22):4119-30.

3. Song M, et al. Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.

4. Zhan Y, et al. Exp Cell Res. 2009 Aug 15;315(14):2343-57.

NSC 87877 (NSC87877;NSC-87877)

生物&药学活性

物理化学性质&存储条件

参考文献

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NSC 87877 (NSC87877;NSC-87877)

生物&药学活性

物理化学性质&存储条件

参考文献

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