NSC 745887 |CAS:54490-26-5 Probechem Biochemicals

Chemical Structure : NSC 745887

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NSC 745887 (NSC745887)

货号: PC-63230Not For Human Use, Lab Use Only.

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.

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生物&药学活性

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.
NSC 745887 increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage.
NSC 745887 suppresses the [18F]-FDG-specific uptake value in brain tumors.

物理化学性质&存储条件

分子量	260.252
分子式	C16H8N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Naphtho[2,3-f]quinoxaline-7,12-dione

参考文献

1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.

NSC 745887 (NSC745887)

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NSC 745887 (NSC745887)

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