NSC697923 | Ubc13 inhibitor | Probechem Biochemicals

Chemical Structure : NSC697923

CAS No.: 343351-67-7

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NSC697923 (NSC 697923)

货号: PC-35686Not For Human Use, Lab Use Only.

NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A.
NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells, inhibits NF-κB activation induced by PMA, but not by TNFα.
NSC697923 specifically inhibits Ubc13-mediated polyubiquitin chain synthesis in vitro, does not inhibits UbcH5c-mediated polyubiquitin chain formation.
NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells.

物理化学性质&存储条件

分子量	267.255
分子式	C11H9NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-nitro-5-tosylfuran

参考文献

1. Pulvino M, et al. Blood. 2012 Aug 23;120(8):1668-77.

2. Cheng J, et al. Cell Death Dis. 2014 Feb 20;5:e1079.

3. Ritorto MS, et al. Nat Commun. 2014 Aug 27;5:4763.

4. Hodge CD, et al. ACS Chem Biol. 2015 Jul 17;10(7):1718-28.

NSC697923 (NSC 697923)

生物&药学活性

物理化学性质&存储条件

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NSC697923 (NSC 697923)

生物&药学活性

物理化学性质&存储条件

参考文献

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