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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Ezrin-NSC668394
NSC668394

Chemical Structure : NSC668394

CAS No.: 382605-72-3

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NSC668394 (NSC 668394, NSC-668394)

货号: PC-36052Not For Human Use, Lab Use Only.

NSC668394 (NSC 668394) is a small molecule inhibitor of Ezrin, directly bind to ezrin with Kd of 12.59 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC668394 (NSC 668394) is a small molecule inhibitor of Ezrin, directly bind to ezrin with Kd of 12.59 uM.
NSC668394 inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels.
NSC668394 inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM.
NSC668394 inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.

物理化学性质&存储条件

分子量 452.102
分子式 C17H12Br2N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-((3,5-dibromo-4-hydroxyphenethyl)amino)quinoline-5,8-dione

参考文献

1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81.

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