NSC 668036 |CAS:144678-63-7 Probechem Biochemicals

Chemical Structure : NSC 668036

CAS No.: 144678-63-7

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NSC 668036 (NSC668036)

货号: PC-61785Not For Human Use, Lab Use Only.

NSC 668036 is a specific inhibitor of the Dishevelled (Dvl) PDZ domain, extremely weakly binds to PSD-95, PSD95, and PDZ7 domain of GRIP.

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5 mg	￥3880	In stock
10 mg	￥5780	In stock
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生物&药学活性

NSC 668036 is a specific inhibitor of the Dishevelled (Dvl) PDZ domain, extremely weakly binds to PSD-95, PSD95, and PDZ7 domain of GRIP.
NSC 668036 inhibits the signaling induced by Wnt3A and blocks Wnt signaling by interrupting the Fz-Dvl interaction.
NSC 668036 suppresses β-catenin-driven gene transcription and abolishes TGF-β1-induced migration, expression of collagen I and α-α-SMA in fibroblasts.
NSC 668036 depresses fibrotic process in vivo.

物理化学性质&存储条件

分子量	460.52
分子式	C21H36N2O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester

参考文献

1. Shan J, et al. Biochemistry. 2005 Nov 29;44(47):15495-503.

2. Wang C, et al. Exp Cell Res. 2015 Feb 1;331(1):115-22.

3. Chen X, et al. J Mol Model. 2009 Jan;15(1):91-6.

NSC 668036 (NSC668036)

生物&药学活性

物理化学性质&存储条件

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NSC 668036 (NSC668036)

生物&药学活性

物理化学性质&存储条件

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