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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Frizzled-NSC654259
NSC654259

Chemical Structure : NSC654259

CAS No.: 150068-95-4

NSC654259 (NSC-654259;NSC 654259)

货号: PC-60868Not For Human Use, Lab Use Only.

NSC654259 is novel small molecule Wnt signaling inhibitor that targets the cysteine-rich domain of Frizzled, specifically binds to the Wnt binding site on the Frizzled 8 (FZD8) cysteine-rich domain with Kd of 2.9 uM, IC50 of 5.7 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC654259 is novel small molecule Wnt signaling inhibitor that targets the cysteine-rich domain of Frizzled, specifically binds to the Wnt binding site on the Frizzled 8 (FZD8) cysteine-rich domain with Kd of 2.9 uM, IC50 of 5.7 uM.

    物理化学性质&存储条件

    分子量 535.783
    分子式 C21H20BrClN6O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-[(2-aminoacetyl)amino]-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-methylphenyl]carbamoyl]benzamide;hydrochloride

    参考文献

    1. Lee HJ, et al. J Biol Chem. 2015 Dec 18;290(51):30596-606.

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