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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-NSC59984
NSC59984

Chemical Structure : NSC59984

CAS No.: 803647-40-7

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NSC59984 (NSC 59984;NSC-59984)

货号: PC-45688Not For Human Use, Lab Use Only.

NSC59984 is a small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells.

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5 mg (Free Sample) ￥180 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC59984 is a small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells.
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway, restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells.
NSC59984 degrades mutant p53R273H, rescued CDH6 expression.
NSC59984 significantly represses DLD-1 xenograft tumor growth.

物理化学性质&存储条件

分子量 265.2652
分子式 C12H15N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 38 mg/mL
Chemical Name/SMILES

2-Propen-1-one, 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-

参考文献

1. Zhang S, et al. Cancer Res. 2015 Sep 15;75(18):3842-52.

2. Karthikeyan S, et al. Oncotarget. 2016 Oct 25;7(43):69871-69882.

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