NSC 45576 |CAS:1414586-62-1 Probechem Biochemicals

Chemical Structure : NSC 45576

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NSC 45576 (NSC45576)

货号: PC-63107Not For Human Use, Lab Use Only.

NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.

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生物&药学活性

NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.
NSC 45576 inhibits cAMP-induced EPAC activation while not affecting PKA activity.
NSC 45576 is a valuable pharmacological tools for elucidating the biological functions of EPAC and for promoting an understanding of disease mechanisms related to EPAC/cAMP signaling.

物理化学性质&存储条件

分子量	378.402
分子式	C20H14N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-(2-oxonaphthalen-1(2H)-ylidene)hydrazinyl)naphthalene-2-sulfonic acid

参考文献

1. Tsalkova T, et al. PLoS One. 2012;7(1):e30441.

2. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.

3. Mizuta K, et al. Respir Res. 2013 Sep 2;14:89.

NSC 45576 (NSC45576)

生物&药学活性

物理化学性质&存储条件

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NSC 45576 (NSC45576)

生物&药学活性

物理化学性质&存储条件

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