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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Alkylator/Crosslinker-NSC373981
NSC373981

Chemical Structure : NSC373981

CAS No.: 95455-02-0

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NSC373981 (NSC 373981)

货号: PC-49195Not For Human Use, Lab Use Only.

NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells.
NSC373981 dose-dependent repression of CARD11 mRNA levels in both ABC DLBCL cells, RIVA and HBL1, and the GCB DLBCL cell.
NSC373981 requires nitro-group for CARD11 G-quadruplex (G4) stabilization and repression of CARD11 transcription.
NSC373981 concurrently represses the expression of BCL2 and MYC, two other key oncogenes in DLBCL.

物理化学性质&存储条件

分子量 257.245
分子式 C14H11NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-nitronaphtho [2,1-b]furan-1-yl)ethan-1-ol

参考文献

1. Kennith Swafford, et al. Genes (Basel). 2022 Jun 25;13(7):1144.

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