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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-NSC 370284
NSC 370284

Chemical Structure : NSC 370284

CAS No.: 116409-29-1

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NSC 370284 (NSC370284, NSC-370284)

货号: PC-62520Not For Human Use, Lab Use Only.

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
NSC 370284 shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.

物理化学性质&存储条件

分子量 387.432
分子式 C21H25NO6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol

参考文献

1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.

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