NSC348884 | Nucleophosmin inhibitor | Probechem Biochemicals

Chemical Structure : NSC348884

CAS No.: 81624-55-7

加入收藏

NSC348884 (NSC 348884)

货号: PC-20788Not For Human Use, Lab Use Only.

NSC348884 is a small molecule nucleophosmin (NPM) inhibitor, disrupts the formation of dimers and inhibits aberrant NPM functionin cancer cells.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NSC348884 is a small molecule nucleophosmin (NPM) inhibitor, disrupts the formation of dimers and inhibits aberrant NPM functionin cancer cells.
NSC348884 inhibits cell proliferation at an IC(50) of 1.7-4.0 uM in distinct cancer cell lines and disrupts NPM oligomer formation by native polyacrylamide gel electrophoresis assay.
NSC348884 upregulates p53 (increased Ser15 phosphorylation) and induces apoptosis in a dose-dependent manner that correlated with apoptotic markers: H2AX phosphorylation, poly(ADP-ribose) polymerase cleavage and Annexin V labeling.
NSC348884 synergizes doxorubicin cytotoxicity on cancer cell viability.

物理化学性质&存储条件

分子量	636.81
分子式	C38H40N10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1,N1,N2,N2-tetrakis((6-methyl-1H-benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine

参考文献

1. Qi W, et al. Oncogene. 2008 Jul 10;27(30):4210-20.

2. Balusu R, et al. Blood. 2011 Sep 15;118(11):3096-106.

NSC348884 (NSC 348884)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NSC348884 (NSC 348884)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.