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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P-glycoprotein (P-gp)-NSC23925B
NSC23925B

Chemical Structure : NSC23925B

CAS No.: 1369591-04-7

NSC23925B (NSC 23925b)

货号: PC-62666Not For Human Use, Lab Use Only.

NSC23925B is a small molecule agent that reverses MDR in cancer cells, reverses MDR in several drug-resistant cell lines expressing P-gp.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC23925B is a small molecule agent that reverses MDR in cancer cells, reverses MDR in several drug-resistant cell lines expressing P-gp.
    NSC23925B resensitizes cancer cell lines to paclitaxel, doxorubicin, mitoxantrone, etc.
    NSC23925B significantly enhances in vivo antitumor activity of paclitaxel in MDR xenograft models, without increasing the level of paclitaxel toxicity.

    物理化学性质&存储条件

    分子量 421.362
    分子式 C22H26Cl2N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-(2-(4-methoxyphenyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol dihydrochloride

    参考文献

    1. Duan Z, et al. J Med Chem. 2012 Apr 12;55(7):3113-21.

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