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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P-glycoprotein (P-gp)-NSC23925
NSC23925

Chemical Structure : NSC23925

CAS No.: 858474-14-3

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NSC23925 (NSC 23925)

货号: PC-62665Not For Human Use, Lab Use Only.

NSC 23925 is a small molecule compound that reverses multiple drug resistance (MDR) in human cancer cell lines, reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC23925 is a small molecule compound that reverses multiple drug resistance (MDR) in human cancer cell lines, reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR.
NSC23925 shows maximal reversal of resistance in SKOV-3TR or OVCAR8TR to cytotoxic drugs is 0.5 uM to 1 uM.
NSC23925 stimulates ATPase activity of Pgp, increases the intracellular accumulation of Pgp1 substrates.

物理化学性质&存储条件

分子量 421.36
分子式 C22H26Cl2N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride

参考文献

1. Duan Z, et al. PLoS One. 2009 Oct 12;4(10):e7415.

2. Duan Z, et al. J Med Chem. 2012 Apr 12;55(7):3113-21.

3. Yang X, et al. Br J Cancer. 2014 Jun 10;110(12):2896-904.

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