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首页-小分子抑制剂&激动剂-Epigenetics-DNA Methyltransferase (DNMT)-NSC232003
NSC232003

Chemical Structure : NSC232003

CAS No.: 1905453-18-0

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NSC232003 (NSC 232003)

货号: PC-49682Not For Human Use, Lab Use Only.

NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation.

物理化学性质&存储条件

分子量 169.14
分子式 C6H7N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-5-(1-(hydroxyamino)ethylidene)pyrimidine-2,4(3H,5H)-dione

参考文献

1. Vassilios Myrianthopoulos, et al. Eur J Med Chem. 2016 May 23;114:390-6.

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