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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-Akt-NSC 177223
NSC 177223

Chemical Structure : NSC 177223

CAS No.: 36707-00-3

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NSC 177223 (API-1)

货号: PC-38489Not For Human Use, Lab Use Only.

NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation.

规格 价格 库存 数量
1 mg ￥1880 In stock
5 mg ￥3880 In stock
10 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation.
NSC 177227 (API-1) does not interfere with PI3K, PDK1, and mTORC1/2 complexes.
NSC 177227 (API-1) is selective for Akt over the AGC kinase members PKA, PKC, and SGK and other signaling molecules ERK, JNK, p38, and STAT3.
NSC 177227 (API-1) inhibits constitutively active Akt and its downstream targets, inhibits cell growth and induces apoptosis in the cells with hyperactivated Akt.
NSC 177227 (API-1) exhibits anti-tumor activity in cancer cell lines with hyperactivated Akt in mouse xenografts.

物理化学性质&存储条件

分子量 337.3
分子式 C13H15N5O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-amino-8-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

参考文献

1. Donghwa Kim, et al. J Biol Chem. 2010 Mar 12;285(11):8383-94.

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