NSC167409 | HMGB1 inhibitor, EV-A71 inhibitor | Probechem Biochemicals

Chemical Structure : NSC167409

CAS No.: 1405-86-3

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NSC167409 (Glycyrrhizin, Glycyrrhizic acid)

货号: PC-24230Not For Human Use, Lab Use Only.

Glycyrrhizin (NSC167409, Glycyrrhizic acid) is a direct HMGB1(high mobility group box 1) inhibitor, also is a specific inhibitor of EV-A71, blocks EV-A71 replication both in vivo and in vitro.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Glycyrrhizin (NSC167409, Glycyrrhizic acid) is a direct HMGB1 (high mobility group box 1) inhibitor, also is a specific inhibitor of EV-A71, blocks EV-A71 replication both in vivo and in vitro.
Glycyrrhizin (NSC167409) inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress.
Glycyrrhizin (NSC167409) modulates P38 and P-JNK but not p-ERK signalling.
Glycyrrhizin (NSC167409) also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

物理化学性质&存储条件

分子量	822.94
分子式	C42H62O16
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-Carboxy-2-(((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

参考文献

1. Jun Li, et al. Nat Commun. 2025 Mar 13;16(1):2513.

NSC167409 (Glycyrrhizin, Glycyrrhizic acid)

生物&药学活性

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NSC167409 (Glycyrrhizin, Glycyrrhizic acid)

生物&药学活性

物理化学性质&存储条件

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