NSC 15765 |CAS:35973-25-2 Probechem Biochemicals

Chemical Structure : NSC 15765

CAS No.: 35973-25-2

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NSC 15765 (Compound C5;DNA2 inhibitor C5)

货号: PC-61784Not For Human Use, Lab Use Only.

NSC 15765 (Compound C5, DNA2 inhibitor C5) is an effective, selective and competitive inhibitor of DNA2 nuclease with IC50 of 20 uM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NSC 15765 (Compound C5, DNA2 inhibitor C5) is an effective, selective and competitive inhibitor of DNA2 nuclease with IC50 of 20 uM.
NSC 15765 poorly inhibits the activities of the other two nucleases, FEN1 and EXO1.
NSC 15765 suppresses resection-related homology directed repair (HDR) and single-stand annealing (SSA) and causes accumulation of phosphorylated RPA foci, and inhibits restart of stalled DNA replication forks and over-resection of nascent DNA in cells defective in fork protection.
NSC 15765 exhibits cytotoxicity against a panel of 18 cell lines with IC50 of 7-70 uM.
NSC 15765 sensitizes cells to PARP inhibitor MK-4827; also sensitizes cells to CPT and synergizes with PARP inhibitors.
NSC 15765 also can mimics DNA2 knockout and synergistically kills cancer cells when combined with an ATR inhibitor.

物理化学性质&存储条件

分子量	234.167
分子式	C10H6N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-nitro-4-oxo-1H-quinoline-3-carboxylic acid

参考文献

1. Liu W, et al. EBioMedicine. 2016 Apr;6:73-86.

2. Li Z, et al. EMBO J. 2018 Jul 13;37(14). pii: e96729.

NSC 15765 (Compound C5;DNA2 inhibitor C5)

生物&药学活性

物理化学性质&存储条件

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NSC 15765 (Compound C5;DNA2 inhibitor C5)

生物&药学活性

物理化学性质&存储条件

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