NSC 146268 (6-Aza-2-thiouridine) | CD151 inhibitor Probechem Biochemicals

Chemical Structure : NSC 146268

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NSC 146268 (NSC146268, 6-Aza-2-thiouridine)

货号: PC-35789Not For Human Use, Lab Use Only.

NSC 146268 (NSC146268, 6-Aza-2-thiouridine) is a novel small molecule inhibitor of CD151, inhibits proliferation of metastatic triple negative breast cancer cell lines (MDA-MB 231 and MDA-MB 468, IC50 of 6.0 and 6.2 ug/mL).

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生物&药学活性

NSC 146268 (NSC146268, 6-Aza-2-thiouridine) is a novel small molecule inhibitor of CD151, inhibits proliferation of metastatic triple negative breast cancer cell lines (MDA-MB 231 and MDA-MB 468, IC50 of 6.0 and 6.2 ug/mL).
NSC 146268 shows little effect on normal breast epithelial cell line (IC50 value 48 ug/mL).
NSC 146268 also exhibits significant anti-proliferative activity comparable to paclitaxel with arrest of cell cycle at G1 phase and induction of apoptosis, decreases protein levels of CD151 together with cell junction scaffold proteins, CD46, E-cadherin, β-catenin and ZO-1.

物理化学性质&存储条件

分子量	261.252
分子式	C8H11N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-sulfanylidene-1,2,4-triazin-5-one

参考文献

1. Murali Mohan Gavara, et al. A novel small molecule inhibitor of CD151 inhibits proliferation of metastatic triple negative breast cancer cell lines. Process Biochemistry Volume 66, March 2018, Pages 254-262. https://doi.org/10.1016/j.procbio.2017.12.004

NSC 146268 (NSC146268, 6-Aza-2-thiouridine)

生物&药学活性

物理化学性质&存储条件

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NSC 146268 (NSC146268, 6-Aza-2-thiouridine)

生物&药学活性

物理化学性质&存储条件

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