NSC 145366 | HSP90 inhibitor | Probechem Biochemicals

Chemical Structure : NSC 145366

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NSC 145366 (NSC145366)

货号: PC-61797Not For Human Use, Lab Use Only.

NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM.

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生物&药学活性

NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM.
SC 145366 increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding.
SC 145366 causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.

物理化学性质&存储条件

分子量	635.371
分子式	C37H63ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[4-[2-[4-[2-hydroxy-3-(2,4,4-trimethylpentan-2-ylamino)propoxy]phenyl]propan-2-yl]phenoxy]-3-(2,4,4-trimethylpentan-2-ylamino)propan-2-ol hydrochloride

参考文献

1. Thomas FM, et al. SLAS Discov. 2017 Jul;22(6):706-719.

2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug;1861(8):1992-2006.

NSC 145366 (NSC145366)

生物&药学活性

物理化学性质&存储条件

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NSC 145366 (NSC145366)

生物&药学活性

物理化学性质&存储条件

参考文献

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