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首页-小分子抑制剂&激动剂-Epigenetics-MicroRNA-NSC141562
NSC141562

Chemical Structure : NSC141562

CAS No.:

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NSC141562 (NS141562, NSC-141562)

货号: PC-60435Not For Human Use, Lab Use Only.

NSC141562 is a potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC141562 is a potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis.
    NSC 141562 strongly inhibits mature miR-155 generation in a timedependent manner in U87 and primary GBM cells.
    NSC 141562 reduces the proliferation, migration and invasion, increases the expression of PCDH9 and PCDH7, decreases the expression of mesenchymal transition-associated markers, N-cadherin, vimentin, MMP9 and β-catenin.

    物理化学性质&存储条件

    分子量 376.302
    分子式 C17H22BrN5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[(2-methylquinolin-3-yl)methyl]-3,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide

    参考文献

    1. Wu X, et al. Neuro Oncol. 2017 Sep 1;19(9):1195-1205.

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