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首页-小分子抑制剂&激动剂-Epigenetics-MicroRNA-NSC 141562
NSC 141562

Chemical Structure : NSC 141562

CAS No.:

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NSC 141562 (NSC141562;NSC-141562)

货号: PC-60435Not For Human Use, Lab Use Only.

A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis; strongly inhibits mature miR-155 generation in a timedependent manner in U87 and primary GBM cells, reduces the proliferation, migration and invasion, increases the expression of PCDH9 and PCDH7, decreases the expression of mesenchymal transition-associated markers, N-cadherin, vimentin, MMP9 and β-catenin.

物理化学性质&存储条件

分子量 376.302
分子式 C17H22BrN5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[(2-methylquinolin-3-yl)methyl]-3,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide

参考文献

1. Wu X, et al. Neuro Oncol. 2017 Sep 1;19(9):1195-1205.

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