NSC13728 hydrochloride | Myc-Max inhibitor | Probechem Biochemicals

Chemical Structure : NSC13728 hydrochloride

CAS No.: 5463-36-5

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NSC13728 hydrochloride (NSC-13728 hydrochloride)

货号: PC-20799Not For Human Use, Lab Use Only.

NSC13728 hydrochloride is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

NSC13728 hydrochloride is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
NSC13728 does not significantly enhance DNA binding of the Myc-Max heterodimer or of the Max homodimer, as determined by EMSA analysis.
NSC13728 reduces the association of Myc with Max in a dose-dependent manner in MCF7-35IM cells.
NSC13728 inhibited the Myc-induced formation of transformed cell foci in CEF and growth inhibition in Q8 cells with IC50 of 3 uM.
NSC13728 inhibits growth and complements growth reduction by ICI 182,780 in MCF7-35IM cells.

物理化学性质&存储条件

分子量	501.12
分子式	C31H37ClN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	bis(4-methyl-2-(piperidin-1-yl)quinolin-6-yl)methane hydrochloride

参考文献

1. Hao Jiang, et al. Mol Pharmacol. 2009 Sep;76(3):491-502.

NSC13728 hydrochloride (NSC-13728 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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NSC13728 hydrochloride (NSC-13728 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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