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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-NSC12
NSC12

Chemical Structure : NSC12

CAS No.: 102586-30-1

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NSC12 (NSC 12, NSC-12)

货号: PC-60628Not For Human Use, Lab Use Only.

NSC12 is an orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3, FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases.

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10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC12 is an orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3, FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases.
NSC12 shows no apparent interaction for the other FGFs.
NSC12 inhibits HSPG/FGF/FGFR ternary complex formation induced by FGFR1(IIIc)-binding FGFs KATO III cells, inhibits FGFR1 phosphorylation in HUVECs stimulated by FGF2 with inhibition of HUVEC proliferation with IC50 of 6.5 uM.
NSC12 demonstrates significant inhibition of H520 tumor growth in vivo.

物理化学性质&存储条件

分子量 484.523
分子式 C24H34F6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3β,20S)-24,24,24-Trifluoro-23-(trifluoromethyl)-21-norchol-5-ene-3,20,23-triol

参考文献

1. Ronca R, et al. Cancer Cell. 2015 Aug 10;28(2):225-39.

2. Castelli R, et al. J Med Chem. 2016 May 26;59(10):4651-63.

3. Ronca R, et al. Oncotarget. 2017 Aug 1;8(47):82583-82592.

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