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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-NSC116565
NSC116565

Chemical Structure : NSC116565

CAS No.: 18903-23-6

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NSC116565

货号: PC-38712Not For Human Use, Lab Use Only.

NSC116565 is a potent, time-dependent inhibitor of Mycobacterium tuberculosis (M.tb) ketol-acid reductoisomerase (KARI) with Ki of 95.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC116565 is a potent, time-dependent inhibitor of Mycobacterium tuberculosis (M.tb) ketol-acid reductoisomerase (KARI) with Ki of 95.4 nM.
    NSC116565 directly binds to MtKARI in the presence and absence of the cofactor, nicotinamide adenine dinucleotide phosphate (NADPH).
    NSC116565 inhibits the growth of H37Ra and H37Rv strains of Mtb with MIC50 values of 2.93 and 6.06 uM, repectively.

    物理化学性质&存储条件

    分子量 199.184
    分子式 C6H5N3O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-hydroxy-2-methylthiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione

    参考文献

    1. Lin X, et al. Chemistry. 2021 Feb 10;27(9):3130-3141.

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