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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-NSC112200
NSC112200

Chemical Structure : NSC112200

CAS No.: 28293-38-1

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NSC112200 (NSC 112200)

货号: PC-63454Not For Human Use, Lab Use Only.

NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2, promotes proteasomal degradation of EZH2 and inhibits the viability of TNBC cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2, promotes proteasomal degradation of EZH2 and inhibits the viability of TNBC cells.
    0NSC112200 is a mixture of 2,5-dibromo-3,6-dimethyl-1,4- benzenediol and 2,5-dibromo-3,6-dimethyl-1,4-benzoquinone.

    物理化学性质&存储条件

    分子量 293.942
    分子式 C8H6Br2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,5-Dibromo-3,6-dimethyl-2,5-cyclohexadiene-1,4-dione

    参考文献

    1. Zhang P, et al. Cell Rep. 2018 Apr 17;23(3):823-837.

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